²¢µæÆP¸É§U¡A¥i¨Ï¹}®Æ¤¤¥Ò²¸

Ói»Ä¡BÁxÆP¤§¨Ï¥Îµo´§³Ì¤j§@¥Î

ºK­n

        Ãö©ó¹}®Æ¤§²¢µæÆP²K¥[¡A¥i´£¨Ñ®a¸V¹}®Æ½Õ»sªÌ¡A¨Ï¥L­Ì¨Ï¥Î¥Ò²¸Ói»Ä¤ÎÁxÆP¡Aµo´§³Ì¤j§@¥Î¤§»¤¤H³~®|¡C²¢µæÆP(BETAINE)¥i´£¨Ñ¹}®Æ¤¤¨Ñµ¹¥Ò°ò®Ú³Ì¦³®Ä¤è¦¡¡A¨Ã­°¾A¦X¦¹¥\¯à¤§ÁxÆP¤Î¥Ò²¸Ói»Ä»Ý­n¶q¡C

        ²¢µæÆP¡B¥Ò²¸Ói»Ä¤ÎÁxÆP»Pºû¥Í¯À»²ú@ºû¥Í¯ÀB6¡B¸­»Ä¤Îºû¥Í¯ÀB12¡A¬°°Êª«¤Î¤HÃþ¹}®Æ¤¤¤§¥Ò°ò®Ú¥D­n¨Ó·½¡C¦]¦b¯«¸g¡B§K¬Ì¡BµÇ¤Î´`Àô¨t²Î¤¤¡A¥Ò°ò¤Æ¤§¾Ô²¤¨¤¦â¡AÁö¤£´¿¾ð¥ß°Êª«¤§¥Ò°ò®Ú»Ý¨D¶q¤§Àç¾i±ÀÂË¡A¦ý¦P·N¨â¦¨ªø¤Î¦¨¼ô°Êª«»Ý­n¨Ñµ¹¤@©w¤§¥Ò°ò®Ú¡A»Ý­n¥Ò°ò®Ú¥H¦X¦¨½Ñ¦p¥Ò²¸Ói»Ä¡B¦×¬rÆP(carnitine)¡A¦Ù®ò»Ä(creatine)¡AÁC¯×Ãþ¡AµÇ¤W¸¢¶Pº¸»X¡ARNA¤ÎDNA¤§¼ÆºØ¥Í²z¤W¥²¶·¤§¤Æ¦Xª«¡C¥Ò°ò®Ú¤§¤£¨¬¬O¡A°ß¤@¨ä¥»¨­·|¥X²{­PÀù¤§¹}®Æ¯Ê¥F¡C

        ¦³Ãö¤W­z¤§¥Ò°ò¤Æ¤ÏÀ³¤¤¤Æ¦Xª«¤§¬Û¹ï¥Í²z¤W¨¤¦â¡A¦bÀç¾i¾ÇªÌ¤§¶¡¡A¦³¨Ç²V²c¤£²M¡C¦b´X¥G©Ò¦³¥NÁ¨t²Î¡A¦Û¥Ò²¸Ói»Ä»PÁC»Ä¸¢úe»Ä(adenosine phosphate)¦X¦¨¤§SAM(S-adenesyl methionine)¡A¬°¥D­n¤§¥Ò°ò®Ú®½Ãت̡C¦b¥Ò²¸Ói»Ä¯à®½Ãبä¥Ò°ò¤§«e¡A¥ý¥²¶·ÂàÅܦ¨SAM¡C¥Ò²¸Ói»Ä¤§¥Ò°ò®Ú¤§¥NÁÂ¥i°Ê©Ê¡A¾É­P¦p¥Íª«¾Ç¤§¤£¦w©w©Ò­zªº¡C¦Û²¢µæÆP¤Î¸­»Ä¡A5-¥Ò°ò¥|²B¸­»Ä(THF)¤§¥Ò°ò«¬¡A¥iÀò±oÃB¥~¤§¤£¦w©w¤§¥Ò°ò®Ú¡C¦bÂàÅÜÃþ¥b¯ÖÓi»Ä¦¨¥Ò²¸Ói»Ä¤¤¡A²¢µæÆP¤§©Ò¦³3­Ó¥Ò²B®Ú¡A¥i§@¥Ò°ò®½Ãت̡A¦b¸Ó³B¡A¦³¾÷Åéºû«ù©ó¥i¯à¥Ò°ò¤Æ¤§¼W°ªª¬ºA¡C¦b¦¹¤ÏÀ³¤¤¡A¥Ñ©óBHMT(betaine-homocysteine¥Ò°òÂಾú@)»Ã¯À¸ô®|¤§¶Ê¤Æ¡A²¢µæÆPª½±µÂಾ¨ä3­Ó¥Ò°ò®Ú¤§¤@(¦b¦¹¨Ò¤l¤¤¡A¤@­Ó¤£¦w©w¤§¥Ò°ò®Ú)¡A¦ÜÃþ¥b¯ÖÓi»Ä¡A³o¼Ë´N§Î¦¨¥Ò²¸Ói»Ä¤ÎÂù¥Ò°ò¥ÌÓi»Ä(dimethylglycine)¡C«e­z¤§Âù¥Ò°ò¥ÌÓi»Ä¡C¦¹«á¥NÁ¤À¸Ñ¦Ü¤@ºÒ·½³æ¦ì¡A¦Û³o¡AÂÇ­«·s§Î¦¨¡AÀò±oTHF«¬¤§¤£¦w©w¥Ò°ò®Ú¡CTHF¤§¤£¦w©w¥Ò°ò®Ú¡A¥i§@¬°»Ã¯À5-¥Ò°ò¥|´á¸­»Ä¤@Ãþ¥b¯ÖÓi»Ä¥Ò°òÂಾú@(FTMT)¡A¦ÛÃþ¥b¯ÖÓi»Ä¦X¦¨¥Ò²¸Ói»Ä¤§²Ä¤G¤Î¥æ´À¸ô®|¤§¥Ò°ò®½Ãت̥ΡC

        ºK­n¤§¡A¦bBHMT¤ÏÀ³¤¤¡A¦ü¥G²¢µæÆP®½Ãبä¥Ò°ò®Ú¤§¤@¡Aª½±µµ¹»PÃþ¥b¯ÖÓi»Ä¡A§Î¦¨¥Ò²¸Ói»Ä¡A¦P®É¨ä¾l¤§¨â²¢µæÆP¤§¥Ò°ò¡B¸gFHMT¸ô®|¡A«Dª½±µ°Ñ»PÃþ¥b¯ÖÓi¤§¥Ò°ò¤Æ¦¨¥Ò²¸Ói»Ä¡C¦b¥]¬AÂû¤§¼ÆºØ°Êª«¡AFHMT¤ÏÀ³¤§¬¡©Ê¡A¸û¤Ö©óBHMT¸ô®|¤§¬¡©Ê¡C´¿²Ö¿n¨¬°÷¤§¼Æ¾Ú¡A¤ä«ù¨Ì¿à²¢µæÆP¥Ò°ò¤Æ¤§­«­n©Ê¡C¦AªÌ¡ABHMT¸ô®|¬°°ß¤@¤§²¢µæÆP(¤ÎÁxÆP)»¼¸Ñ¤èªk¡A¤Î¬°¥Ò²¸Ói»Ä¥Í²£¤§¥D­n½Õ¸`ªÌ¡C

        ¦b¥Ò²¸Ói»ÄÄá¨ú¤§¥úÃШâºÝ¡ABHMTú@¤§¬¡©Ê¼W¥[¡A¦¹»Ã¯À¡A¬¡©Ê¦ü¥G¬O¡A¦b¤£¾A·í¤§¥Ò²¸Ói»ÄÄá¨ú¤Î¬°­n²¾Âà¹L¶q¥Ò²¸Ói»ÄÄá¨ú«á¤§¹L¶qÃþ¥b¯ÖÓi»Ä´Á¶¡¡Aºû«ù¥Ò²¸Ói»Ä¿@«×¤§¤@ºØÅãµÛ¤èªk¡C

        ¦]ÁxÆP¥»¨­¡A¨ä¥Ò°ò®Ú¨S¦³¤£¦w©w¡A¤£¬O¥Ò°ò®½Ãت̡C¥u¦³¦b¸g²¢µæÆPîǦܲ¢µæÆP¤§¨â¨BÆJ½u²ÉÅ餧®ñ¤Æ«á¡AÁxÆP¤§¥Ò°ò¤~·|Åܦ¨¤£¦w©w¡C¾ÚStekol¤§¬ã¨s¡A¹ï¦¹Âà´«¤§®Ä²v¡A¦³¬Y¨Çª½±µÃÒ¾Ú¡C´N¬O¦Û²¢µæÆP¤§¤£¦w¥Ò°ò®Ú¡A¤ñ¦ÛÁxÆP¤§¥Ò°ò®Ú¡A¸û¦³®ÄªºÂಾ¦Ü¥Ò²¸Ói»Ä©Î¯ÖÓi»Ä¡C¾ÚBaker¤ÎCzarnecki(1985)¤§³ø§i¡A¦b©w¶qÃþ¥b¯ÖÓi»Ä§@¥Ò²¸Ói»Ä«eÅX®Ä²v¤§¬ã¨s¡B²¢µæÆP¯à¼W°ªÃþ¥b¯ÖÓi»Ä¦Ü¥Ò²¸Ói»Ä¸ô®|¡A¦ýÁxÆP¤£¯à¡C

        ÁöµM¹}®Æ¤§Á`§t²¸Ói°ò»Ä¡B·|ÅãµÛ¼vÅT¥Ò²¸Ói»Ä²£¥Í¤§BHMT¸ô®|¤§¬¡©Ê¡A¦ýÁxÆP®ñ¤Æú@¤§¬¡©Ê¡A¦ü¥G¤£¨ü¼vÅT¡C¦b¹ïBHMTú@¬¡©Ê¤§¼vÅT¡AÁxÆP»P²¢µæÆP¤§¶¡¡A¦³ÅãµÛ®t²§¡F0.2¢H¹}®Æ¤§ÁxÆP¡A²£¥ÍBHMTú@¬¡©Ê¡A«DÅãµÛªº36¢H¼W¥[¡A¦Ó0.2¢H²¢µæÆP¡A²£¥Í¬Û·í¤§ÅãµÛ2.3¢H¼W¥[¡C¸ÕÅç«Ç¤§¬ã¨sµo²{¡AÅã¥Ü¤£¹³²¢µæÆP¡A¹}®Æ¤§ÁxÆP¨³³t¶i¤JÅé¯×¡A¦]¦¹¨Ï¨ä¹ï¨x¤§¥Ò°ò¤Æ¡A¸û¨S¦³®Ä¡C

        ¹ï¥Ò°ò¤Æ»Ý­n¦h¤Ö¤§¹}®Æ¥Ò²¸Ói»Ä¡H¾Ú«Ü¦³®ÄªºÁxÆPÂàÅܦ¨²¢µæÆP°²©w¤§Â_©w¡AMudd¤ó(1975¡F1980)¤§¸ê®Æ¦ô­p¡A¦bÁxÆPÂন²¢µæÆP«á¡A¦Û¹}®ÆÁxÆPÀò±o¡A¤HÃþ»Ý­n¬ù0.35mmol¡þ¨C¤Ñ¨CkgÅé­«¤§¥Ò°ò®Ú¡A¤Î¬ù0.05mmol¡þ¨C¤Ñ¨CkgÅé­«(¦h14¢H)¤§¦¹»Ý¨D¶q¡C¾ÚÂû¤§¥Ò°ò¤Æ»Ý¨D¶q¤§¦ô­p¬O¥¼¯à±Ä¥Î¡A¨ÑSounderson¤ÎMackinlay(1990)¤§¬ã¨sªí¥Ü¡A¹}®Æ¥Ò²¸Ói»Ä¤§¤j³¡¥÷¬OÂনSAM¡C

        ´¿¸gªí¥Ü¡A¹ïÂಾ¥Ò°ò¤Æ¡A¬ù90¢H¤§Âû¤§­n¨D¶q¡A¥²»Ý¥ÑSAM«¬¤§¥Ò²¸Ói»Ä§¹¦¨¡C¦b½Ñ¦p¯e¯f¤§§Üºò­¢¤U¡A¦ü¥G¼W¥[¹ïSAM¤§»Ý¨D¡A¦]»Ý­n¥Ò°ò¤Æ¤ÏÀ³¡A¥Hºc¿v§K¬Ì¨¾Å@¾÷ºc¤Î¦X¦¨§ê²Õ´­×¸É¹Lµ{¨¤¦â¤§¦hÓi¡CTsiagbeµ¥µo²{¡A³Ì¤j¦¨ªø¤§¥Ò²¸Ói»Ä»Ý¨D¶q¡A§C©ó³Ì¤j§ÜÅé¤ÏÀ³¤§»Ý¨D¶q¡A¥B¹}®Æ¤§ÁxÆP¡A¹ï¬ã¨s¤§§K¬ÌÅܤƵL¼vÅT¡C¹ï³J¥Õ½è¦X¦¨¡ASAM¦A¦^õX¦¨¥Ò²¸Ói»Ä«Ü­«­n¡CµM¦ÓÃþ¥b¯ÖÓi»Ä¥i³QBHMT©ÎFHMT¡A¦A¥Ò°ò¤Æ¦¨¥Ò²¸Ói»Ä¡A¤]¥i¯à¸g¤@³æ¤è¦VÂಸ¤ÏÀ³¡A³Q¥NÁ¤À¸Ñ¦¨cystathionine¡A¦¹ª«³Ì«á³Q¶Ê¤Æ¦¨¤@ହT»ÄÆQ¤Î¥b¯ÖÓi»Ä¡C¾ÚFinkelstein(1990)¤§³ø§i¡A¦bµ¹»P¥­¿Å¹}®Æ¤§¹«¡A¬ù45¢H¤§Ãþ¥b¯ÖÓi»Ä¡A·|ÂàÅܦ¨cystathionine¡CMudd¤ÎPoole(1975)¦ô­p¡A¦bµ¹»P¥­¿Å¹}®Æ¤§¨k¤H¡A53¢H¤§¦³®ÄÃþ¥b¯ÖÓi»Ä¡A·|ÂàÅܦ¨¯Ö²¸îÅ(cystathionine)¡A¦ýÀH¹}¾i¯Ê¥F¥Ò²¸Ói»Ä¹}®Æ¤§«á¡A·|­°¨ì20¢H¡C

        ¦¹µo²{ªí¥Ü¡A¦b¯Ê¥F¥Ò²¸Ói»Ä±ø¥ó¤U¡A¦³ÅãµÛ¶q¤§¥Ò²¸Ói»Ä¡A¥i¯à¿ò¥¢©ó(¥b)¯ÖÓi»Ä¦X¦¨¡C³oÂI¤]ÃÒ¹ê¡A¹}®Æ¤§(¥b)¯ÖÓi»Ä§t¶q¡A¯à¼vÅT°Êª«¤§¥Ò²¸Ói»Ä»Ý¨D¶q¡A¥BÂû¡B½Þ¤Î¹«¤§Á`§t²¸Ói°ò»Ä»Ý¨D¶q¤§¢H¡A¥i¥Ñ¯ÖÓi¾©Î¥b¯ÖÓi»Ä¨ÑÀ³¡CFinkelstein¤ÎMudd(1967)ªí¥Ü¡A¹}®Æ¤§(¥b)¯ÖÓi»Ä»²§U¡A¾É­PÅãµÛªº¸û°ª¤ô·Ç¤§BHMTú@¬¡©Ê¡A¬Æ­P·í¹}®Æ¤§¥Ò²¸Ói»Ä¾A·í®É¡C

        ¥L­ÌÂ_¨¥¡A³o¨ÇÅܤƤ§¥NÁ®ĪG¡A¥i¯à´£°ª¥Ò²¸Ói»Äº¢¯d¤Î´î¤ÖÂಾ²¸§@¥Î¡C³oÂI¬Oªí¥Ü¡AµL»Ý­nÃþ¥b¯ÖÓi»Ä¤§¹}®Æ·½¡A¥H§ïµ½¥Ò²¸Ói»Ä¤§¦³®Ä©Ê¡A¦]¥b¯ÖÓi»Ä«YÀ³¦Û¥Î©ó¥Ò°ò¤Æ¤§¥Ò²¸Ói»Ä(SAM)¡C

        ¦b®a¸VÀç¾i»â°ì¡A¬O²Ä¤@­­¨îÓi°ò»Ä¡A§ïµ½¥Ò²¸Ói»Äº¢¯d¤§¹ê»Ú§t·N³Ì©úÅã¡CµÛªÌ­Ì´¿§Q¥ÎÃä»Ú¤§¥Ò²¸Ói¯Ê¥F(20~25¢H)¹ê¥Î¥É¦Ì¢w¶À¨§¯»¹}®Æ(ªí¤W)¡A¥H¦×Âû§@«Ü¦h¬ã¨s¡C¦¹¸ÕÅç«Y¦b²Ö¿n¹Ô®Æ¤W¹ê»Ú±ø¥ó¤U¹ê¬I¡A¦]¦¹¸ÕÅçÂû¦³¼ÉÅS©ó¯fµß¬D¾Ô¤§¥¿±`¤ô·Ç¡A¥B¹}®Æ¦³¤@¯ë±µ¨ü¤§±a¦³Â÷¤l¤§§Ü²yÂξ¯¤Î¦¨ªø«P¶i¾¯»²§U¡C¦Û©Ò¦³¸ÕÅç¸ê®ÆÅã¥Ü¡A¦b¦¨ªø©Î¹}®Æ¡þ¼W­«©Î¨âªÌ¡A¹ï²K¥[¥Ò²¸Ói»Ä¡A¦³ÅãµÛ¤ÏÀ³¡C°£³æ¿W¸ÕÅç¡Aµ¹»P0.05¢H²¢µæÆPÂû¹}®Æ¡A¤ñ¨º¨Çµ¹»P0.1~0.15¢H²¢µæÆP©Î0.50~0.075¢H²¢µæÆP¡C¦×Âû¤§®Ä¯à¬O¤@¼Ë¡C

ªí¡G¦b¤£¦P²yÂΧðÀ»¤ô·Ç¤U¡A§Q¥Î¦×Âû¤§¥Ò²¸Ói»Ä¡þ²¢µæÆP¬Û¤¬§@¥Î¸ÕÅç

¬ã¨s³õ©Ò ¸ÕÅçr¼Æ ¥Ò²¸Ói»Ä¤§°ò¥»¤ô·Ç¢H ²K¥[¤§ÁxÆP¤ô·Çsf¡þrr¡þfi ²K¥[¤§¥Ò²¸Ói»Äppm ²K¥[¤§²¢µæÆP¢H ³Ì²×Åé­«¢H ³Ì²×¤§¹}®Æ¡þ¼W­«kg
¬ìù©Ô¦h«~½è 47 0.38¡þ0.37¡þ0.30 520¡þ510¡þ360 ¢w ¢w 2.336b 1.808ab
¬ã¨s¤½¥q 47 0.38¡þ0.37¡þ0.30 520¡þ510¡þ360 0.15 ¢w 2.380a 1.792a
²M¼ä 47 0.38¡þ0.37¡þ0.30 520¡þ510¡þ360 ¢w 0.075 2.372a 1.788a
¬ìù©Ô¦h«~½è 47 0.42¡þ0.42¡þ0.35 520¡þ510¡þ360 ¢w ¢w 2.339ab 1.841bc
¬ã¨s¤½¥q 47 0.42¡þ0.42¡þ0.35 520¡þ510¡þ360 0.10 ¢w 2.380a 1.792a
§ðÀ» 47 0.38¡þ0.37¡þ0.30 520¡þ510¡þ360 ¢w 0.05 2.350ab 1.804ab
¬ìù©Ô¦h«~½è 47 0.38¡þ0.37¡þ0.30 520¡þ610¡þ360 ¢w ¢w 2.276c 1.875d
¬ã¨s¤½¥q 47 0.38¡þ0.37¡þ0.30 520¡þ610¡þ360 0.15 ¢w 2.325b 1.846
§ðÀ» 47 0.38¡þ0.37¡þ0.30 520¡þ610¡þ360 ¢w 0.075 2.310bc 1.835bc
¬ìù©Ô¦h«~½è 47 0.42¡þ0.42¡þ0.35 520¡þ510¡þ360 ¢w ¢w 2.291c 1.853c
¬ã¨s¤½¥q 47 0.42¡þ0.42¡þ0.35 520¡þ510¡þ360 0.10 ¢w 2.325bc 1.846c
§ðÀ» 47 0.42¡þ0.40¡þ0.35 520¡þ510¡þ360 ¢w 0.05 2.317bc 1.823b
¬ìù©Ô¦h«~½è 47 0.42¡þ0.42¡þ0.35 360¡þ360¡þ180 ¢w ¢w 2.110x 1.932x
¬ã¨s¤½¥q 47 0.40¡þ0.36¡þ0.31 360¡þ360¡þ180 0.15 ¢w 2.170y 1.902z
§ðÀ» 42 0.40¡þ0.36¡þ0.31 360¡þ360¡þ180 ¢w 2.132xy 1.915y ¡@
¡@ 42 0.40¡þ0.36¡þ0.31 360¡þ360¡þ180 ¢w 0.75 2.165y 1.905z
¡@ 42 0.40¡þ0.36¡þ0.31 360¡þ360¡þ180 ¢w 0.10 1.163y 1.902z

        ©Ò¦³¹}®Æ¬O¥H±ÀÂˤ§ÁxÆP°Ó·~©Ê¤ô·Ç²K¥[¡A¦¹ÂI»PNRC(1994)±ÀÂˤ@­P¡C¦]¦¹¡AJackson(1996)±ÀÂ_¡A¶È¦bÁxÆP¯Ê¥F¹}®Æ½T¹ê©Ê¤U¡A²¢µæÆP¯à¸`¬Ù¥Ò²¸Ói»Ä¡C¦b¦¹¦a§e²{¤§¸ê®Æ¡A¤]»PFinkelstein(1983)¤ÎBaker©MCzarneaki(1985)¤§µo²{¤@­P¡A¥Lªº¸ê®Æ«ü¥X¡A¦b¨ë¿EBHMTú@¬¡©Ê¤W¡AÁxÆPµL®Ä¡C

        ¦bµL¯fµß¤ÎµL¬D¾Ô¹êÅç«ÇÀô¹Ò¡A¹ïSAM»Ý¨D¶q¡A¤j¦h¥i¯à´î¦Ü³Ì¤Ö¶q¡A¥B¦³®Ä«ì´_Ãþ¥b¯ÖÓi»Ä¦Ü¸û¤Ö¶q¡C¹ïµ¹»P§C(¥b)¯ÖÓi»ÄÂû¹}®Æ¡A¦]¦b«e­z±ø¥ó¤U¡A¦¹ÂI¤]¬O¯uªº¡A±N´î¤Ö»Ý¨D¶q¡A¥H¸`¬Ù¦³²K¥[¥Ò°ò®½Ãت̤§¥Ò²¸Ói»Ä¡C¦b¹ê»Ú¤§³¥¥~±ø¥ó¡A¦]»Ý­n¸gÃþ¥b¯ÖÓi»Ä«ì´_²¢µæÆP¡A¹ïSAM²£¥Í¤§¥Ò²¸Ói»Ä»Ý¨D¶q¡A«Ü¥i¯à¼W¥[¡C

        ¸ê®ÆÅã¥Ü¡A¦b¹ê»Ú³¥¥~±ø¥ó¤U¡A¦b«P¶i¦¨ªø¤Î¹}®Æ®Ä²v¤W¡A²¢µæÆP¤ñ¥Ò²¸Ói»Ä¸û¦³®Ä¡A¨Ñµ¹¹}®Æ¤§¥Ò²¸Ói»Ä¤ô·Ç¡A¨S¦³¹³¦¹¦a¤Þ¥Î¤§¬ã¨s¨º¼Ë­­¨î¡C

¹Ï¡B¦b²¢µæÆP¡BÁxÆP¤Î¥Ò²¸Ói»Ä¤§¹Ï¥NÁ¬۹Ï

97¦~01´ÁP95.GIF (6116 bytes)

¹}®ÆÀç¾iÂø»x(p.93¡ã97)¢w³¯«p°ò¡B¤E¤C¦~¤@´Á